Abstract
Objective: Attention deficit hyperactivity disorder (ADHD) is one of the most frequently seen neuropsychiatric disorders in childhood. The aim of this study is to compare the efficacy and the adverse effects of two FDA-approved agents, atomoxetine (ATX) and osmotic release oral system methylphenidate (OROS-MPH), in the treatment of ADHD. Material and Methods: This research was designed as a randomized, open label, prospective and follow-up study. The study was performed by 120 cases between ages 7-16 years who were diagnosed as ADHD for the first time and given prescription. The cases were divided into two by randomization. One group was given ATX (n=59) while the other was given OROS-MPH (n=61) were evaluated prospectively by clinical examination and Conner's Comprehensive Behavior Rating Scale-Teacher (CRS-T) at the 2nd, 4th, and 6th months. Efficacy of treatment was regarded as a 40% reduction in CRS-T scores when compared to baseline values, and the adverse effects were questioned in every follow up visit. Results: The efficacy was 55.7% in CRS-T hyperactivity score, 63.9% in the attention deficit score, and 55.7% in the behavior problems score in OROS-MPH group. Those values were 47.5%, 69.5% and 57.6% respectively in ATX group. Adverse effects were seen in 27.1% (n=16) of the patients in the ATX group, and in 31.1% (n=19) of the patients in the OROS-MPH group. Two groups were not found significantly different for the frequency of adverse effects as well as the efficacy of the medication, at the follow-up evaluations which were performed at 2nd, 4th and 6th months. Conclusion: In this study, ATX and OROS-MPH were compared for their efficacy and adverse effects for the treatment of ADHD, and two agents were found similar for their efficacies and adverse effect profiles. ATX and OROS-MPH have similar efficacies in the treatment of ADHD and adverse effect profiles are similar.
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