Abstract
Summary1) The effect of streptomycin on the cysteine desulfhydrase in cell free extracts of E. coli is reported. 2) 2.5 μg of streptomycin/1 mg of crude extract protein caused almost complete inhibition of enzyme activity. 3) Inhibition is of a non-competitive type, since it is not reversed by increasing concentrations of substrate. 4) Inhibition is irreversible, since the removal of streptomycin by prolonged dialysis did not cause a restoration of enzyme activity.
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