Dihydropyrimidinones: Recent Synthetic and Pharmacological Perspectives with Special Focus on Colon Cancer

Abstract

The most important heterocyclic complexes involved in the manufacture of DNA and RNA are dihydropyrimidines. Through multi-component synthetic procedures like the Biginelli reaction and the Hantzsch dihydropyridine reaction, they were created. Due to their extraordinary biological properties, dihydropyrimidin-2(1H)-ones/thiones (DHPMs) are notable heterocyclic compounds. Dihydropyrimidin-2(1H)-ones/thiones (DHPMs), among the most important heterocyclic compounds, have biologically important properties such as cytotoxic, antibacterial, antiviral, and anti-inflammatory effects. As a result, organic and medicinal chemists are paying increasing attention to the synthesis of DHPMs and their derivatives. Many DHPM compounds have recently been isolated, described, and identified, and they are currently undergoing human usage studies. Dihydrpyrimidines have been discovered to improve the health of cancer patients. We are intrigued by dihydropyrimidine research and its focus on colon cancer. One of the most prevalent kinds of cancer is colorectal cancer (CRC), and it’s also the second commonest fatal malignancy for both sexes combined and the third most frequent diagnosis. With the exception of younger persons, both the incidence of new cases and death have been consistently dropping over the past several years, maybe as a result of increased cancer screening and improved treatment options. Different dihydropyridine calcium channel blockers prevent calcium from entering certain human cancer cells, having anticancer effects. However, to our knowledge, the anticancer impact of dihydropyrimidine on colorectal cancer cells has never been studied (CRC). With an emphasis on colon cancer, we have attempted to discuss the significance of DHPM derivatives for a number of chronic and developmental problems in this article.