Abstract
V˙/Q˙ mismatch and the loss of hypoxic pulmonary vasoconstriction play a pivotal role in the pathophysiology of COVID-19 respiratory distress.1,2 Dihydropyridine calcium channel blockers (CCBs), frequently prescribed first-line antihypertensive agents, have the potential to disrupt hypoxic pulmonary vasoconstriction3 and worsen V̇/Q̇ mismatch that leads to profound hypoxemia in patients with pulmonary disease.4 We hypothesized that CCBs would be associated with worse respiratory failure in patients with COVID-19.
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