Abstract
Dihomo-γ-linolenate effectively prevented the irreversible aggregation of human platelets induced by collagen or epinephrine. Also, platelets from rats which received daily oral doses of dihomo-γ-linolenate showed significant reductions in platelet aggregatory responses to collagen and ADP which were attributable to increases in plasma and platelet ratios of dihomo-γ-linolenate to arachidonate. Similar results were obtained in rabbits. This data, together with that of enzymatic studies supports a hypothesis that oral ingestion of dihomo-γ-linolenate may effectively prevent arterial thrombosis in man by causing a redirection of platelet prostaglandin biosynthesis. Thus PGE 1 and its non-aggregatory endoperoxide intermediate (PGR 1) are formed at the expense of PGE 2 and LASS endoperoxide which together may induce platelet thrombus formation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
