Abstract
Our first study of maturation and renal digoxin clearance [1] revealed a greater variability and higher mean ratio of digoxin clearance to creatinine clearance in infants and children than in adults. The data suggested that this ratio, which represents the net renal tubular secretion of digoxin, decreases during puberty. However, this initial study included too few subjects in the appropriate age group to verify this possibility. Subsequent work [2] confirmed that the net renal tubular secretion of digoxin decreases during adolescence. It appears that the decrease in net renal tubular secretion of digoxin from childhood to adulthood correlates better with full sexual maturation at puberty (Tanner stages 4 and 5) than with chronologic age. In this paper, we will review the above findings and report our further analysis of the data by gender.
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