Abstract
The precise pathogenesis o f the inf lammatory process o f intestinal non-occlusive ischemia which can result in intestinal gangrene in patients receiving digoxin (DIG), a cardiotonic drug, is debatable. To prove the hypothesis that, in addit ion to the vasoconstr ic tor effect o f D I G and a cardiac-induced low-flow state [1], accelerated coagulation leading to thrombosis in the intestinal microvasculature is responsible for this lethal condition, this study was carried out. To demonst ra te the presence o f hypercoagulabil i ty, the modified recalcification time (MRT) test was utilized. The M R T is made highly sensitive by incorporat ing both the cellular (platelet and monocyte) and the chemical part icipants in the assessment o f hypercoagulabil i ty. Details o f the rationale and me thodo logy of the M R T were summarized in a recent report [2].
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Schedule a callMore From: Inflammation research : official journal of the European Histamine Research Society ... [et al.]
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