Digital twin of renal system with CT-radiography for the early diagnosis of chronic kidney diseases

Abstract

Kidney failure, also called as end-stage renal disease is the final stage of chronic kidney disease(CKD). Kidney failure cannot be revered and is the life-threatening if left untreated. Hence there is a demand for the early and automatic detection of CKD from radiology images based on deep learning techniques. This work focuses on the diagnosis of the predominant CKDs such as kidney stone, cyst and tumor from CT scan images. CT scan abdomen and urogram images are used to construct the digital-twin for the diagnosis of CKD in the robust manner. The proposed work is based on the dataset which contains 12,446 unique CT scan images, within it in which the cyst contains 3,709, normal 5,077, stone 1,377, and tumor 2,283. Deep features are extracted from these images and generated hyper edges from these features. These features are used to construct hypergraph representing the renal images. These hypergraphs are used in hypergraph convolutional neural network for representational learning. Finally, the model is validated by hold-out dataset. Deep learning metrics including precision, recall, accuracy, and FI score are used to validate the proposed model. It outperforms compared to other state of art algorithms with a superior validation accuracy of 99.71. The proposed model is a robust digital-twin for the early diagnosis of kidney diseases. It will assist the nephrologist for the better prognosis of kidney related abnormalities.