(Digital Presentation) A Review on the Control of Biofilms by Cold-Plasma Technology

Abstract

Today, biofilm infection is considered a challenge in the field of medicine and biomedical physics and engineering, as it includes 80% of infections worldwide. The complex architecture of the matrix of the extracellular polymeric substance of the biofilm, which houses the microbial cells, is resistant to antimicrobials and detergents. Cold Plasma anti-bio film application is a novel solution to address this challenge. This review study focuses on different parameters and factors affecting the mechanism of plasma-biofilm interaction in two types: direct and indirect processing. The first phase, the direct application of plasma, focuses on the direct processing of biofilms by cold plasma generators. The second phase, the indirect application of plasma is dealt with plasma surface engineering for biomaterial and medical devices which are in contact with the human body. As is known reduction in microbial load and biofilm removal by direct plasma processing is achievable and efficient. This microbial reduction also can happen by plasma surface engineering as an indirect solution, in which the plasma-treated biomaterial surface will gain an antimicrobial property and consequently mitigate biofilm growth. Moreover, the penetration depth of plasma in biofilms and the application of plasma surface pretreatment with 3D printing as a next-generation manufacturing approach have been reviewed. This review study sheds light on the efficient factors in this mechanism. This clarification helps how to optimize the control of biofilms by cold plasma technology.