Digit ratio (2D:4D) and its behavioral correlates in infant rhesus macaques (Macaca mulatta).

Abstract

2D:4D ratios are typically lower in adult human males than females and are linked to numerous sex-differentiated behaviors. 2D:4D ratios are considered an indicator of prenatal androgen exposure; if so, children's 2D:4D ratios would arguably be even better indicators of prenatal androgen exposure since children have experienced fewer postnatal influences than adults. However, sex differences in 2D:4D ratios as well as associations between 2D:4D ratios and sex-typed behaviors in children have been inconsistent. Several studies also report sex differences and behavioral correlates of 2D:4D ratios in adult non-human primates, but little is known about 2D:4D ratios in infant non-human primates. This study examined sex differences in 2D:4D ratios over the first month of life, and associations with behavioral outcomes at 12-24weeks of age, in N=304 infant rhesus macaques. An increase in 2D:4D ratios over the first month of life was found, as well as associations with aggression and play behaviors, but no sex differences in 2D:4D ratios were observed. These results highlight the need for future developmental studies of 2D:4D ratios in order to determine not only their stability and predictive value, but also to discern the mechanism connecting prenatal androgen exposure, 2D:4D ratios, and behavioral outcomes.