Abstract
AbstractA synthetic strategy for producing new difunctional molecules for potential use as radiolabelling precursors derived from [11C]cyanide is presented. No‐carrier‐added [11C]CN− was reacted with chloromethyl pivalate to generate the nitrile [11C]cyanomethyl pivalate, which was subsequently converted to ethyl 1 [1‐11C]glycolate, 2, with acid and alcohol, or to [1‐11C]glycolic acid, 4, using aqueous acid. [1‐11C]Ethylene glycol, 3, and [2‐11C]2‐aminoethanol 5, were obtained by reduction of2 and 1, respectively, with lithium aluminum hydride. Conditions for obtaining conversions ca. 90% are described. By using a microwave wave‐guide cavity to speed up transformations requiring elevated temperatures, all five carbon‐11 labelled compounds were synthesized in less than a total of 3 min.
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