Abstract
Difluoromethyl 2-pyridyl sulfone was first reported in 2010, and since then it has been widely used in the synthesis of various structurally diverse organofluorine compounds. This chapter provides an overview of the synthetic applications of difluoromethyl 2-pyridyl sulfone and gives some mechanistic insights into these transformations, including gem-difluoroolefination, difluoroalkylation, and 2-pyridination. By applying these transformations, a variety of bioactive molecules and functional material precursors were obtained. Some of the applications are highlighted in this chapter.
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