Abstract
Conventional magnetic resonance (MR) imaging (MRI) is widely used for the diagnosis of multiple sclerosis (MS), because of its ability to demonstrate the presence of central nervous system (CNS) lesions with dissemination in space and time [1]. In addition, when monitoring the evolution of MS, serial brain MRI scans may disclose the occurrence of disease activity and the accumulation of disease burden with a greater sensitivity than the clinical assessment of relapses and neurological disability. Nevertheless, since a clear discrepancy between clinical and conventional MRI findings in patients with established MS has emerged from most of the available studies [2], there is an urgent need for more accurate neuroimaging techniques to monitor MS evolution.
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