Abstract
Single-shot line scan imaging (LSI) was adapted to diffusion-weighted (DW) MRI by replacing the initial 90 degrees radiofrequency pulse of the underlying high-speed stimulated echo sequence by a DW spin-echo preparation period. Implementation on a 2. 0 T whole-body MRI system yielded DW images of the human brain with b factors of 750 s mm(-2) and total imaging times of about 500 ms either for a single slice at 1.5 x 3.0 x 6 mm(3) resolution or simultaneously for up to seven slices at 3.75 x 3.75 x 8 mm(3) resolution. Isotropic DW images and maps of the trace of the diffusion tensor were calculated from four scans with different combinations of three orthogonal diffusion gradients. DW LSI combines high speed with robustness against image artifacts caused by motion (no phase ghosting) and tissue susceptibility differences (no signal losses, no geometric distortions). Because the latter is an important advantage over echo-planar imaging, DW LSI may find useful applications despite a limited signal-to-noise ratio. Magn Reson Med 42:772-778, 1999.
Highlights
Single-shot line scan imaging (LSI) was adapted to diffusion- signal-to-noise ratio (SNR) due to the use of low flip angle weighted (DW) MRI by replacing the initial 90° radiofrequency pulse of the underlying high-speed stimulated echo sequence by a DW spin-echo preparation period
To investigate the influence of partial saturation on the apparent diffusion coefficient (ADC) calculated from four DW scans, the delay time between successive measurements was varied from 12 s to 1 s
Single-shot LSI using stimulated echoes was adapted to multi-slice DW MRI and applied to isotropic diffusion mapping of the human brain on a conventional 2.0 T whole-body scanner
Summary
Single-shot line scan imaging (LSI) was adapted to diffusion- signal-to-noise ratio (SNR) due to the use of low flip angle weighted (DW) MRI by replacing the initial 90° radiofrequency pulse of the underlying high-speed stimulated echo sequence by a DW spin-echo preparation period. The approach employs a image artifacts caused by motion (no phase ghosting) and tissue susceptibility differences (no signal losses, no geometric distortions). Because the latter is an important advantage over echo-planar imaging, DW LSI may find useful applications despite a limited signal-to-noise ratio. The purpose of this work is the development of a DW variant of a single-shot high-speed LSI technique based on stimulated echoes [17]. It combines the robustness of LSI against motion artifacts and susceptibility problems with subsecond acquisition times even without a gradient perfor-. Pertinent phase distortions are amplified in the MATERIALS AND METHODS
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