Abstract
Purpose: Assessment of disease progression in patients with incipient osteoarthritis (OA) remains a major challenge. Quantitative imaging biomarkers have the advantage of being sensitive to changes in cartilage composition, which represent an early feature of the disease. Several MRI parameters have shown sensitive to proteoglycan content, but only T2 relaxation time being partially sensitive to collagen. DTI was introduced as a biomarker specific for proteoglycan content (MD) and collagen structure (FA) and has demonstrated to be a promising biomarker to diagnose OA.
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