Diffusion Tensor Imaging as a Promising Radiological Biomarker of Disability, Disease Load, and Activity in Multiple Sclerosis

Abstract

The recent MRI brain techniques are potential biomarkers of MS lesion activity and disability. This study aimed to determine the cutoff values of Diffusion Tensor Imaging parameters correlated to the disease activity in multiple sclerosis (MS). This study included fifty MS cases and thirty age and sex-matched healthy controls were included. Axial fast spin-echo T1, T2, and 3D high-resolution T2 FLAIR images were carried out for all patients. Also delayed post-Gadolinium T1 images were obtained in MS cases for assessment of plaque activity. Diffusion Tensor Imaging (DTI) was obtained to assess the white matter tract, disease burden, and activity.