Abstract
The diffusion of quinidine sulphate through a polydimethylsiloxane film containing 20% SiO 2 filler was studied in a cell with two stirred compartments separating the film, taking into account all the forms (neutral, mono- and di-protonated) of quinidine in the buffered aqueous solutions of the cell compartments. The theoretical treatment leads to a relationship between the quinidine concentration across the film thickness as a function of the diffusion time, allowing for the chemical reactions in the cell compartments at constant pH, the solubility of quinidine in the polymer phase and the adsorption of quinidine onto the SiO 2 phase. A solution for large values of time is given, showing a linear dependence of In Δc on time.
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