Abstract
In the study of artificial blood oxygenation, the mechanism of oxygen diffusion and absorption in a blood film is of particular interest. An equation was derived for the diffusion of oxygen into whole blood films that are thick compared to the red cell size. The equation, which was solved on an electronic analogue computer, showed that simple expressions for an advancing interface of oxygenated blood are good approximations. An equation for a blood film bounded by a semipermeable membrane was also derived. An experiment was conducted to confirm the advancing interface theory. In a second experiment, the diffusivity of oxygen in whole blood was found to be approximately 1.3 (10–5) cm2/sec. When using highly permeable membranes, such as silicone rubber, in a blood oxygenator, the relative permeabilities of a blood film and the membrane are such that in many cases the resistance of the blood film is the controlling factor. Submitted on October 5, 1959
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