Abstract
The purpose of this study is to determine the ability of fluorescent nanoparticles to diffuseinto a crystalline lens. Intact porcine lenses from five-month-old pigs, intact human lensesobtained from three donors aged 41, 42 and 45 years, and sections of human lens cortexobtained from four donors aged 11, 19, 32, and 34 years were incubated for 72 h at7 °C in aqueous solutions of green (566 nm) and red (652 nm) fluorescent water soluble cadmiumtellurium (CdTe) nanoparticles. As demonstrated by fluorescent and confocalmicroscopy, the CdTe nanoparticles diffused into the porcine and human lenscapsule and into human cortical lens fibres; however, the nanoparticles did not passthrough the intact lens capsule. Nanoparticles can be used as a method for studyingintracellular structure and biochemical pathways within the lens capsule and corticallens fibres to further understand cataractogenesis and may serve as a carrier forchemotherapeutic agents for the potential treatment of primary and secondarycataracts.
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