Diffusion magnetic resonance imaging early detect the radiotherapy response of glioma

Abstract

Objective To evaluate the role of diffusion magnetic resonance imaging(MRI) in early detection of the treatment response of radiation for glioma. Method Conventional and diffusion MRI were acquired before and at 3 weeks later after initiating radiotherapy for newly diagnosed glioma patients,who had partial tumor resection. ANOVA was used to compare the diffusion MRI parameters among different treatment response groups. Receiver operating characteristic (ROC) curve was used for judgment of sensitivity and specificity of the parameters. Results There was no statistically significant differences (P>0.05) of the pretreatment apparent diffusion coefficient (ADC), ADC during treatment, ADC subtraction value, pretreatment accumulated ADC value,accumulated ADC value during treatment among partial response (PR) group, stable disease(SD) group and progressive disease (PD) group patients. There was statistical differences (P<0.05) of accumulated ADC change percentage among the groups. The predictive value and overall accuracy for early detection of treatment response by the accumulated ADC change percentage was 92.7%. The sensitivity and specificity for predicting PD patients were 81.9% and 96.2% respectively. Conclusions Diffusion MRI could predict the radiotherapy response of glioma patients. Accumulated ADC change percentage is a good parameter for the early detection of PD patients during the treatment of radiation. Key words: Diffusion magnetic resonance imaging; Glioma; Radiosurgery; Prognosis; Iimaging predictor