Diffusion coefficients of phenylbutazone in supercritical CO2 and in ethanol

Abstract

The diffusion coefficients D12 of phenylbutazone at infinite dilution in supercritical CO2 were measured by the chromatographic impulse response (CIR) method. The measurements were carried out over the temperature range from 308.2 to 343.2K at pressures up to 40.0MPa. In addition, the D12 data of phenylbutazone at infinite dilution in ethanol were also measured by the Taylor dispersion method at 298.2–333.2K and at atmospheric pressure. The D12 value of phenylbutazone increased from 4.45×10−10m2s−1 at 298.2K and 0.1MPa in ethanol to about 1.43×10−8m2s−1 at 343.2K and 14.0MPa in supercritical CO2. It was found that all diffusion data of phenylbutazone measured in this study in supercritical CO2 and in ethanol can be satisfactorily represented by the hydrodynamic equation over a wide range of fluid viscosity from supercritical state to liquid state with average absolute relative deviation of 5.4% for 112 data points.