Abstract
Neonatal rat stratum corneum was used as a model membrane to investigate the diffusion of surfactants through mammalian skin. Passage of materials through these membranes was determined by use of radiotagged compounds and by spectrophotometric analysis. The anionic surfactant sodium lauryl sulfate penetrates the stratum corneum even at low concentrations. The diffusion constant for this process is about 10 −10 cm 2/sec, compared to 10 −6 cm 2/sec for free diffusion in water. This surfactant is bound to the skin in large amounts, exceeding 50% by weight at high concentrations. Pretreatment of the membrane by a cationic cellulose polymer (which is itself strongly sorbed) greatly reduced the amount of surfactant which passed through the membrane.
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