Abstract
Diffusion of sugars was measured across surviving rat diaphragm. Selective properties of this living barrier were shown by the fact that galactose moved across it much faster than glucose. Insulin slowed down the diffusion of those sugars whose uptake is known to be accelerated by the hormone. Anti-insulin serum and glucagon had an opposite effect. Diffusion of glucose was also slowed down by anoxia and electrical stimulation and accelerated by adrenaline and 2,4-dinitrophenol. Diffusion of xylose was enhanced by the presence of glucose. These results are easier to interpret in terms of the specific sugar-binding properties of the cellular matrix than according to the membrane-permeability theory.
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