Abstract
AbstractFour groups of Sprague-Dawley rats (15 rats/sex/group) were exposed by whole body to analytically measured concentrations of 0 (control), 0.23, 1.25, or 5.8 ppm bis/2-(dimethylamino)ethyl ether (DMAEE) vapor for 6 h/day, 5 days/wk, for 14 wk. Ten rats/sex/group were euthanized after the exposure regimen, and 5 rats/sex/group were euthanized after a 6-wk recovery period. An additional 3 rats/sex, exposed to 0 and 5.8 ppm, were sequentially sacrificed following 1, 3, or 5 exposures for electron microscopic evaluation. The only systemic toxicity was reduced body weight gain for the 5.8 ppm group throughout the exposure regmen. Clinical signs of ocular and nasal tract irritation (swollen eyelids and periocular and perinasal encrustation) were observed, primarily in the 5.8 ppm group, during the exposure and recovery periods. An ophthalmic examination, following 13 wk of exposure, revealed keratitis in males from the 5.8 ppm group and females from the 1.25 and 5.8 ppm groups. At necropsy, diffuse corne...
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