Abstract
Diffuse sclerosing variant of papillary thyroid carcinoma presenting as suspected cervical osseous metastasis: a case report and literature review
Highlights
The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is a rare variant of PTC, with prevalence of 0.3%~5.3% [1, 2]. It was firstly described by Vicky et al [3] as a variant of PTC in 1985 and was named “DSV-PTC” in the World Health Organization (WHO) classification [2]
It is associated with a genetic alteration different from conventional PTC (C-PTC)
While the BRAF mutation is more common in C-PTC, the RET/PTC rearrangement is the major genetic alteration in DSV-PTC [5]
Summary
The diffuse sclerosing variant of papillary thyroid carcinoma (DSV-PTC) is a rare variant of PTC, with prevalence of 0.3%~5.3% [1, 2]. It was firstly described by Vicky et al [3] as a variant of PTC in 1985 and was named “DSV-PTC” in the World Health Organization (WHO) classification [2] It has unique histologic features such as diffuse and dense sclerosis, numerous calcifications including psammoma bodies, squamous metaplasia, and a background of lymphocytic thyroiditis [5]. Several syncytial fragments of medium-sized cells were observed, including papillary fronds, atypical nuclei with the typical features of papillary carcinoma such as nuclear enlargement and pleomorphism, an irregular nuclear membrane, grooves, and scattered intranuclear inclusions With these typical PTC-like cellular appearances, predominant squamous metaplastic epithelium and abundant psammoma bodies were observed with small lymphocytic infiltration.
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