Abstract
Background Patients with single ventricle (SV) circulations are at risk for heart failure, frequently burdened by both systolic and diastolic cardiac dysfunction. The mechanisms of adverse remodeling of functionally univentricular hearts are incompletely understood. Diffuse myocardial fibrosis is one of the candidate morphological substrates, for which cardiac magnetic resonance (CMR) derived native T1 times and extracellular volume fraction (ECV) have been used as markers. The purpose of this pilot study was to explore whether there is evidence of accelerated myocardial fibrosis in young children after the Fontan operation using CMR.
Highlights
Patients with single ventricle (SV) circulations are at risk for heart failure, frequently burdened by both systolic and diastolic cardiac dysfunction
Despite the younger age native T1 times were longer in the dominant ventricles of SV patients than those in the LVs of the control group (1013 ± 26 ms in dominant LVs [p = 0.007], and 1056 ± 36 ms in dominant right ventricles (RVs) [p = 0.01] vs. 982 ± 26 ms in LVs of controls, Figure)
extracellular volume fraction (ECV) in SV patients with dominant LVs was similar to that of controls while ECV in dominant RVs was increased (23 ± 3% in dominant LVs [p = 0.5], and 29 ± 3% in dominant RVs [p = 0.002], vs. 22 ± 3% in LVs of controls, Figure)
Summary
Diffuse myocardial fibrosis in patients after Fontan operation: a T1 relaxometry magnetic resonance pilot study. Atsuko Kato*, Eugenie Riesenkampff, Deane Yim, Shi-Joon Yoo, Mike Seed, Lars Grosse-Wortmann. From 19th Annual SCMR Scientific Sessions Los Angeles, CA, USA. From 19th Annual SCMR Scientific Sessions Los Angeles, CA, USA. 27-30 January 2016
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
