Abstract
Paraneoplastic dermatomyositis (DM) associated with testicular cancer is extremely rare. We report the case of a patient with skin tightening, polymyalgia, hypereosinophilia, and nodular regenerative hyperplasia revealing seminoma and associated paraneoplastic DM.
Highlights
Dermatomyositis (DM) encompasses a heterogeneous group of multisystemic inflammatory myopathies with variable clinical and laboratory characteristics, affecting mainly the skin and proximal skeletal musculature [1, 2]
We have reported the case of a patient presenting with testicular cancer, hypereosinophilia, and nodular regenerative hyperplasia (NRH) unveiling the diagnosis of amyopathic DM
NRH could explain the elevation of hepatic enzymes but the relationship with muscle weakness could not be made at that time
Summary
Dermatomyositis (DM) encompasses a heterogeneous group of multisystemic inflammatory myopathies with variable clinical and laboratory characteristics, affecting mainly the skin and proximal skeletal musculature [1, 2]. Diagnosis of DM can be made on the basis of biopsy-confirmed classical skin findings, proximal muscle weakness, and elevated muscle enzymes (creatinin Phosphokinase, CPK; Aldolase). The risk of developing a specific type of neoplasia with DM is variable following different populations [4, 6, 8]. Patients with older age at onset of disease (>45 years) and male gender are more likely to develop malignant diseases [5, 7]. We hereby report the case of a patient with fibromyalgialike syndrome and testicular cancer revealing dermatomyositis
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