Abstract
Diffuse large B-cell lymphoma, leg type, is a rare variant of primary cutaneous B-cell lymphomas. It typically presents as rapidly enlarging solitary or multiple violaceous nodules on the lower extremities. Even with adequate treatment with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone, recurrence and systemic spread is common. Timely treatment is necessary as this malignancy is associated with a more aggressive course than other variants of primary cutaneous B-cell lymphomas and overall prognosis is poor.
Highlights
Primary cutaneous B-cell lymphoma (PCBCL) is a special case of B-cell lymphoma that presents on the skin with no evidence of extracutaneous manifestations
Detection and treatment is essential as DLBCLLT has a more aggressive clinical course compared to other types of PCBCL
We present a rare case of bilateral DLBCLLT in an 80-year-old male
Summary
Primary cutaneous B-cell lymphoma (PCBCL) is a special case of B-cell lymphoma that presents on the skin with no evidence of extracutaneous manifestations. Diffuse large B-cell Lymphoma, leg type (DLBCLLT) is a rare variant that compromises only 20% of all PCBCLs and commonly presents as primary cutaneous lesions on the lower extremities.[1,2]. An 80-year-old Hispanic male was referred by his primary care physician to our dermatology clinic for 5 large bumps that first appeared on his left shin 8 months ago. The patient believed they started from a spider bite while working in the backyard. He notes the lesions are associated with pruritis, have increased in size, and expressed yellowish discharge.
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