Diffuse Gastrointestinal Polyposis With Skin, Hair, and Nail Changes

Abstract

Question: A 54-year-old, previously healthy man presented with a 5-kg weight loss, loss of taste, diarrhea, abdominal cramping, hair loss, skin hyperpigmentation, and fingernail changes over the course of 2 months. He endorsed about 6 bowel movements per day with some blood when wiping. Physical examination showed brittle changes of the fingernails and hyperpigmentation of the palmar aspect of both hands (Figure A) and face (Figure B). He denied any joint pain or eye issues. He worked as a contractor with no known toxic exposures and denied any recent travel.