Abstract
s / Pancreatology 14 (2014) S1eS129 S42 extracted and pooled to estimate sensitivity, specificity and diagnostic odds ratios using Bayesian Hierarchical Summary ROC methods. Data are presented as portions s(95% Confidence Intervals). Results: Of 1373 studies, 55 were suitable for inclusion (37 cohort studies, 18 case-control) evaluating 27 different tests. Forty-five percent (2453/5441) of individuals had a diagnosis of CP; the prevalence of CP within cohort studies ranged from 0.12 to 0.94. Diagnostic sensitivity ranged from 0.12 to 1 and specificity from 0.16 to 1. Endoscopic ultrasound (EUS) was the most extensively evaluated diagnostic test being the focus of 16 studies, using different diagnostic models; however, EUS showed the highest pooled sensitivity at 0.90 (0.78,0.96). The accuracy of MR was improved by the addition of secretin: sensitivity 0.81 (0.66,0.9) vs. 0.83 (0.56,0.95); specificity 0.8 (0.61,0.91) vs. 0.89 (0.76,0.96). Conclusion: A wide range of tests for CP have been evaluated in heterogeneous populations making comparison challenging. EUS and secretin MR show good sensitivity and specificity, but specific diagnostic parameters have to be defined to ensure optimum diagnostic utility.
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