Abstract
Introduction-Insulin exerts metabolic and growth-stimulating actions both through its own receptors and the receptors of its homologous factors (IGFs), although with different degrees of affinity. The A receptor of insulin acts more intensely on the cell membrane, with a metabolic response, whereas the B receptor is quickly internalized, stimulates cell growth, can be directed to the treatment of wounds difficult to heal. Objective-we proposes to evaluate the potential of insulin as an inducing agent in the regeneration of wounds that are difficult to heal as a therapeutic option. Methodology-Simultaneous intra and perilesional injections of 0.01ml of the solution containing 5UI of NPH single-component insulin diluted in 1 ml of lidocaine into various planes and wound sites. Clinical, glycemic and photographic evaluations of the patients were performed. Results-The cicatricial response occured in all patients and observed since the first applications. Withouth glycemic changes. Comments - The responses obtained can be attributed to both the stimulation of insulin receptors and that of their counterparts. Conclusions-The method was effective and without adverse effects. Different intervals between applications did not change the results. The availability of insulin and safety for its use indicate the method as a therapeutic option in difficult to heal wounds.
Highlights
Insulin exerts metabolic and growth-stimulating actions both through its own receptors and the receptors of its homologous factors (IGFs), with different degrees of affinity
Insulin-like growth factors (IGF-1 and IGF-2) were originally considered involved only in regulating cell growth, both insulin and IGFs are capable of modifying glucose uptake and cell growth through translocation of different receptors (IR, IGF1-1R and IGF2-2R) [1,2,3,4] that are expressed by all types of animal cells
Insulin binds to its 1Rs receptors with higher affinity than to IGF1-1R, whereas to IGFs 1 and 2 bind to their cognate receptors with greater affinity than insulin 1Rs
Summary
Insulin exerts metabolic and growth-stimulating actions both through its own receptors and the receptors of its homologous factors (IGFs), with different degrees of affinity. The A receptor of insulin acts more intensely on the cell membrane, with a metabolic response, whereas the B receptor is quickly internalized, stimulates cell growth, can be directed to the treatment of wounds difficult to heal. The availability of insulin and safety for its use indicate the method as a therapeutic option in difficult to heal wounds. [7] The receptor A (IR-A) is quickly internalized in response to insulin than the B receptor (IR-B), stimulating gene transcription through mitogen activated protein kinase (MAPK). IR-B predominates in adult differentiated tissues, regulating glucose homeostasis. [8]
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