Abstract
Ventricular assist devices may in few cases be associated with reverse remodelling and functional improvement. We previously showed that progressive atrophy associated with ventricular mechanical unloading resulted in gradual loss of cardiomyocytes, shift of myocyte/connective tissue ratio, increase in myocardial stiffness and time dependent modifications of the ventricular contractile capacity. In the present study, we hypothesized that unloading regulates genes involved in extracellular matrix remodelling, fetal reprogramming, muscle activity and apoptosis/autophagy in a time dependent manner.
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