Abstract
Retinoidal activity of retinoic acid isomers [all- trans -retinoic acid (ATRA), 9- cis -retinoic acid (9CRA) and 13- cis -retinoic acid (13CRA)] and their oxidized derivatives [19-hydroxy and 19-oxo derivatives of ATRA (19-hydroxy-ATRA and 19-oxo-ATRA), 19-oxo derivative of 9CRA (19-oxo-9CRA), and 19-hydroxy derivative of 13CRA (19-hydroxy-13CRA)] was evaluated by means of a human promyelocytic leukemia HL-60 cell differentiation induction assay. All the compounds examined showed this activity with ED 50 values of 2–30 nM, which are in accordance with their binding activity to nuclear retinoic acid receptors (RARs).
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