Abstract
Background: The effects of Panax ginseng C. A. Meyer in protecting and promoting the differentiation of muscle cells have been reported. However, the influences of various ginseng species and various fractions were not investigated.<BR>Methods and Results: In this study, these effects on muscle cells were confirmed using butanol and water fractions of various ginseng species. The fractions of P. ginseng were confirmed to have a cytoprotective effect on C2C12 cells. The myogenin expression level was significantly higher by 1.5 times or more, in the P. ginseng fraction groups than in the other groups, confirming that the P. ginseng fractions promoted cell differentiation. Both fractions of P. ginseng significantly reduced the rate of production of reactive oxygen species when compared with that of the control group. In the mechanism study, P. ginseng fractions tended to decrease muscle RING-finger protein-1 (MuRF-1), AMP-activated protein kinase (AMPK), forkhead box O3α (Foxo3α), and the expression of the BCL2-associated agonist of cell death (BAD). In particular, AMPK was significantly reduced in the P. ginseng water fraction group when compared to that in the butanol fraction and control groups.<BR>Conclusions: The results of this study confirmed that P. ginseng has superior cell differentiation-promoting and protective effects on muscle cells when compared with the effects of Panax quinquefolium and Panax notoginseng.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
