Abstract
The development of the lysosomal system in cells of the renal proximal tubule in newborn and adult rats was studied by electron microscopy using morphometric and histochemical methods. In cells of the renal vesicle and S-shaped body, endocytic vacuoles and lysosomes were rare whereas the Golgi apparatus was prominent. The relative volume of endocytic vacuoles and lysosomes gradually increased after onset of glomerular filtration whereas the surface area of Golgi membranes per unit cell volume decreased. Microbodies (peroxisomes) first appeared in a late developmental stage after glomerular filtration had started. The observations suggest that the growth of the lysosomal system may be induced by the glomerular filtrate and that the Golgi apparatus contributes membranes to this system. In addition, tracer studies with peroxidase indicate that glomerular filtration first occurs in nephrons, where the proximal tubule cells show a simple cuboidal shape and almost no brush border.
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