Abstract
Publisher Summary This chapter discusses the differentiation of the bacterial cell division site. The division site has a developmental history in which the stages of genesis, maturation, and localization, and ultimate fate are considered. The chapter describes the evidence obtained from several disciplines: genetics, microscopy, and biochemistry. In most bacterial species, cell division occurs by the ingrowth of a division septum at the midpoint of the cell. This process is under strict topological and temporal control. The chapter discusses the problem in subcellular differentiation, in which a complex structure is constructed at a specific location in the cell in a process that must be coordinated with a variety of other cellular events, most notably with chromosome replication and segregation. The chapter describes the differences between eukaryotic and prokaryotic cell division and the aspects of bacterial cell envelope organization and chromosomal replication that are relevant to division process. Significant advances have been made in defining the Escherichia coli cell division process. The combined application of genetics with other techniques to study cell division in this organism is emphasized.
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