Abstract
The process of differentiation of photoreceptor disc membrane in mice has been studied by a freeze-fracturing technique. The topographic distribution of the intramembranous particles associated with the rhodopsin indicates that the assembly of the proteins and of the lipids in disc membrane is not synchronous. The differentiation of the disc membrane which occurs after birth, is associated with a progressive increase in density of the intramembranous particles. At the early stages of differentiation, three classes of intramembranous particles can be identified according to their size. When the differentiation process is completed, the average particle size has a diameter of 6·7 nm.
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