Abstract
Mast cells are a progeny of multipotential hematopoietic stem cells. However, the differentiation processes of mast cells are unique and different from those of other progenies of stem cells. First, we will describe the unique differentiation processes of mast cells. In contrast with the unique differentiation processes, regulation mechanisms of mast-cell differentiation appear to be comparable to those of other progenies of hematopoietic stem cells. Second, we will describe regulation mechanisms of mast-cell differentiation. Mast cells are observed in various tissues of the body, and phenotypes of mast cells are different from tissue to tissue. However, the phenotypes of mast cells are not rigidly determined, and can be changed with experimental manipulations. Third, we will describe the phenotypic change between mast-cell subpopulations.
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