Abstract
Mice were treated with Halothane (0.5 % in O 2) 1 hr daily for 4 weeks. During this period, enzyme activities and substrate contents were measured in the liver and compared with the livers of untreated mice. During Halothane treatment, the relative liver weight increased rapidly (30–50 per cent in the first week) while protein and glycogen content of the liver and the general enzyme pattern remained constant (related per g liver wt.); that means that a coordinate growth occurs. Only few enzymes changed in their activity; there was a decrease in the enzyme activity of pyruvate kinase and an increase of malic enzyme and glycerol-1-phosphate oxidase activity. The substrate content in the trioses of the Embden Meyerhof chain was diminished, whereas substrates of the citric acid cycle were increased. The effects observed are discussed with respect to the observations made by other authors and compared with the effects after barbiturate treatment.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
