Abstract

Succinoyl trehalose lipid (STL) and mannosylerythritol lipid (MEL) inhibited the growth of a human promyelocytic leukemia cell line, HL60, and induced their morphological changes. STL and MEL markedly increased common differentiation-associated characteristics in monocytes and granulocytes, such as nitroblue tetrazolium reducing ability, appearance of Fc receptor, phagocytic activities in HL60. The results of non-esterase activity showed that STL induced monocytoic differentiation while MEL induced granulocytic differentiation.

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