Abstract
Naive B cells participate in the humoral immune responses after proliferation and differentiation in the peripheral lymphoid tissues. This fumction of naive B cells needs the help of follicular helper T (Tfh) cells, which are one of the important subset of T helper cells expressing high level of CXCR5. Recent researches show that transcriptional regulator Bcl-6, as well as some other factors such as IL-21, ICOS, T-B cell interaction and antibody affinity play important roles in the differentiation of Tfh. Moreover, deregulation of Tfh cells, up or down-expression of Tfh cell-associated molecules may contribute to autoimmune diseases or tumor. Key words: Follicular helper T cells; CXCR5; Bcl-6; Immune disease
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