Differentiation of enynes and alkynes in asymmetric multicomponent reactions by Pd catalysis

Abstract

In this issue of Chem Catalysis , Chen and co-workers describe a chemo- and stereodivergent asymmetric multicomponent reaction (AMCR) involving two different alkynes under palladium catalysis. Through the elaborate manipulation of catalytic conditions, the reactions selectively afford chiral tetra-substituted alkenes or N -heterocycles bearing an exocyclic double bond in either E - or Z -configuration. In this issue of Chem Catalysis , Chen and co-workers describe a chemo- and stereodivergent asymmetric multicomponent reaction (AMCR) involving two different alkynes under palladium catalysis. Through the elaborate manipulation of catalytic conditions, the reactions selectively afford chiral tetra-substituted alkenes or N -heterocycles bearing an exocyclic double bond in either E - or Z -configuration.