Differentiation Between Ependymoma and Medulloblastoma in Children with Radiomics Approach

Abstract

Ependymoma (EP) and medulloblastoma (MB) of children are similar in age, location, manifestations and symptoms. Therefore, it is difficult to differentiate them through visual observation in clinical diagnosis. The aim of this study is to investigate the effectiveness of radiomics and machine-learning techniques on multimodal magnetic resonance imaging (MRI) in distinguish EP from MB. Three dimensional (3D) tumors were semi-automatic segmented by radiologists from postcontrast T1-weighted images and apparent diffusion coefficient maps in 51 patients (24 EPs, 27 MBs). Then, we extracted radiomics features and further reduced them by three feature selection methods. For each feature selection method, 4 classifiers were adopted which yield 12 different models. After extensive crossvalidation, pairwise test were carried out in receiver operating characteristic curves to explore performance of these models. The radiomics model built with multivariable logistic regression as feature selection method and random forests as classifier had the best performance, area under the curve achieved 0.91 (95 % confidence interval 0.787-0.968). Five relevant features were highly correlated to discriminate EP and MB, which may used as imaging biomarkers to predict the kinds of tumors. The combination of radiomics and machine-learning approach on 3D multimodal MRI could well distinguish EP and MB of childhood, which assistant doctors in clinical diagnosis. Since there is no uniform model to obtained best performance for every specific data set, it is necessary to try different combination methods.