Abstract
Distinguishing between diseases of the anterior horn cell and motor-predominant neuropathies can be challenging. However, making this distinction is important as potentially reversible conditions can otherwise be missed. The disease spectrum ranges from inherited neuronopathies, such as spinal muscular atrophy to acquired neuropathies, such as multifocal motor neuropathy with conduction block. The approach to differentiating between these two groups of disorders through careful evaluation of clinical characteristics, investigations and response to therapy will be discussed.
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