Abstract
The purpose of current study was to evaluate different optical coherence tomography angiography (OCTA) metrics in eyes with diabetic retinopathy with and without diabetic macular edema (DME). In this retrospective study, macular OCTA images of eyes with non-proliferative or proliferative diabetic retinopathy were evaluated. Vascular density, vascular complexity and non-perfusion densities were compared between eyes with and without DME. One-hundred-thirty-eight eyes of 92 diabetic patients including 49 eyes with DME were included. In multivariate analysis, the presence of DME was positively associated with geometric perfusion deficit (GPD) in superficial capillary plexus (SCP), capillary non-perfusion (CNP) of SCP, and GPD in deep capillary plexus (DCP) (all P < 0.05). In eyes with DME, central foveal thickness was associated with VD ratio (SCP/DCP) (P = 0.001) and FAZ area (P = 0.001). In conclusion, in eyes with diabetic retinopathy, the presence of DME was associated with more extensive capillary non-perfusion compared to those with no macular edema.
Highlights
Diabetic retinopathy (DR) and diabetic macular edema (DME) are the main causes of severe visual loss in adult population[1,2]
The extent of capillary non-perfusion was higher and vessel density was lower in eyes with DME, in both superficial capillary plexus (SCP) and deep capillary plexus (DCP)
Traditional staging of diabetic retinopathy based on Early Treatment of Diabetic Retinopathy Study (ETDRS), which is still the gold standard for its classification, describes the proliferative and non-proliferative stages of diabetic r etinopathy[26]
Summary
Diabetic retinopathy (DR) and diabetic macular edema (DME) are the main causes of severe visual loss in adult population[1,2]. Several studies have reported characteristic fluorescein angiography features associated with progression of diabetic retinopathy, and development and severity of diabetic macular edema[3,4,5]. Optical coherence tomography angiography (OCTA), a non-invasive modality that provides depthresolved images from retinal microvasculature has replaced FA in many patients[6,7]. Different OCTA metrics have been shown to predict the presence and the stages of diabetic r etinopathy[7,8,9,10]. Studies reporting OCTA characteristics of diabetic eyes with macular edema are limited. The current study aims to assess different OCTA metrics in eyes with DME compared to diabetic eyes without macular edema
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