Abstract
A pot to share: A CalkylCl bond can be rendered “dormant” or “active” in the Negishi alkyl–alkyl cross-coupling by a simple solvent polarity “switch” (see scheme). Adjustment from a 1:2 to a 2:1 solvent ratio of dimethylimidazolidinone:tetrahydrofuran enables orthogonal alkyl–alkyl Negishi cross-coupling strategies to be carried out on bifunctional bromochloroalkanes in one pot at room temperature.
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