Abstract
Objective: Differentiated vulvar intraepithelial neoplasia (dVIN) is a challenging histopathological diagnosis because of its resemblance to vulvar non-neoplastic epithelial disorders (NNED), lichen sclerosus (LS) in particular. In this study the morphological features of dVIN to establish the most specific and reproducible features were quantified. To further add to the objectivity in dVIN diagnosis, combined immunohistochemistry with CK13 and CK17 was assessed.
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