Abstract
AbstractIn the present study, the possible functional modifications of both D‐1 and D‐2 dopamine (DA) receptor subtypes have been studied following chronic treatment with DA antagonists that selectively act on a single class of DA receptors. Particularly, the functional state of D‐1 and D‐2 receptors has been evaluated by measuring SKF 82526‐stimulated and bromocriptine‐inhibited adenylate cyclase activity in different brain regions of rats treated with saline, SCH 23390, or (−)sulpiride for 35 days.The results indicate that in striatum, nucleus accumbens, and substantia nigra, chronic blockade of D‐1 DA receptors by SCH 23390 induces up‐regulation of D‐1 receptors without changing the functional activity of D‐2 receptors. Likewise, chronic blockade of D‐2 DA receptors by (−)sulpiride causes an up‐regulation of D‐2 but not D‐1 DA receptors in striatum, nucleus accumbens, and substantia nigra. SCH 23390 or (−)sulpiride did not modify the functional activity of either D‐1 or D‐2 DA receptors located in frontal cortex and hippocampus. In conclusion, these results indicate that treatment with selective D‐1 or D‐2 DA receptor blockade for 5 weeks induces a receptor‐specific up‐regulation which involves the DA receptors located in the nigrostriatal system but not those present in the limbic‐cortical areas.
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