Differential Transcriptome Immunomodulatory Profile of an Adjuvanted Modified Grass Immunotherapy in Subjects with Seasonal Allergic Rhinitis and Rhinoconjuctivitis

Abstract

An exploratory field trial in grass allergic subjects was conducted using PQ Grass, a modified grass allergen subcutaneous immunotherapy in combination with an adjuvant system of Microcrystalline Tyrosine and Monophosphoryl Lipid A. Changes in immunomodulatory profile of PQ Grass were explored via transcriptome analysis of peripheral blood from eligible subjects.