Abstract
Mitochondria were prepared from the heart, kidney and brain of rats intoxicated with fluoroacetate. Incubation with several substrates showed depression of respiration of heart mitochondria with pyruvate and succinate, and depression of respiration of kidney mitcohondria with pyruvate, succinate, citrate, β-oxobutyrate and l-glutamate; no inhibition of respiration was detected in brain mitochondria. Phosphorylative capacity, as expressed by the P:O ratio, was not affected in any of the tissues. However, a reduction of the respiratory control was observed in all cases.
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